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DNA methylation is an epigenetic modification characterized by the addition of a methyl group to a DNA molecule. As DNA methylation is implicated in both normal biological processes, such as development and aging, and disease states like cancer and neurological disorders, DNA methylation analyses provide valuable insights into health and disease.

In this ‘Ask the Experts’ feature, Per Hoffman (Life & Brain Genomics; Bonn, Germany), Robert Hillary (University of Edinburgh; UK), and Jörg Tost (Centre National de Recherche en Génomique Humaine; Evry, France), discuss their perspectives and top tips for DNA methylation studies.